# Member of Technical Staff - Computational Biologist - Company: [Valthos]() - Location: New York · San Francisco - Team: Engineering - Employment type: Full Time - Posted: August 29, 2025 ## Job description # Computational Biologist *Valthos Inc.* Valthos is an applied biological intelligence company. We build and deploy software and biological AI systems to safeguard humanity. The same AI architectures that enable self-driving cars, land rockets with precision, and deliver expert-level reasoning are beginning to be deployed in biological design. To stay ahead, we must advance our arsenal of tools to capture and design against real-time sensitivities in nature’s evolving mutational landscape. We are a group of mission-driven software engineers from Palantir and applied biological ML engineers from MIT’s Broad Institute and DeepMind making the latest advances in computational biology accessible in the real-world for federal and commercial use. We are seeking a highly skilled **Computational Biologist** to bridge machine learning and biology by building robust data and evaluation frameworks for assessing and responding to biological threats, and for rapidly designing precision biologics. ## The Role * Contribute to shaping and executing the Valthos-wide research and development roadmap * Identify large-scale biological datasets appropriate for training frontier biological models, and build workflows and infrastructure for processing these datasets * Design, build, and apply evaluation frameworks for rigorously assessing model performance on real-world problems in biological security * Design wet-lab experiments to evaluate the efficacy and real-world utility of designed biologics * Collaborate closely with AI engineers to design and train models tailored to tasks in biological security and precision biologics * Collaborate closely with software engineers to build and deploy tools for data analysis, including proper documentation and testing * Visualize and communicate results clearly within Valthos and externally * Work with customers and external collaborators to understand their needs and effectively represent Valthos * Embrace continuous learning in both technical and non-technical areas across Valthos * Stay up-to-date on state-of-the-art methods at the intersection of AI and biology ## Qualifications (required) * Experience analyzing biological datasets, ideally sequence-based modalities (e.g., genomic, protein, metagenomic) * Experience planning and running *in silico* computational biology experiments * High proficiency in Python and its scientific package ecosystem * Experience with bioinformatics sequence analysis tools (e.g., aligners) * Experience with cloud computing platforms (e.g., AWS) ## Qualifications (preferred) * Proven ability to design, implement, and evaluate novel methods in computational biology * Experience working with experimental biologists to plan and interpret the results of wet-lab experiments * Experience with ML-centric bioinformatics and structure-based tools (e.g., AlphaFold) * Knowledge of biological databases (e.g., NCBI) * Experience with machine learning model training and evaluation * Contributions to open-source projects If there is a fit, we'll schedule two technical interviews. The final step is an onsite in our office, where you'll work on a small project, discuss ideas, and work with the wider team. ## Apply [Apply on Valthos]() Canonical job page: